New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

这些发现阐明了将DNA损伤与免疫激活联系起来的机制，并强调了USP7抑制剂作为放射免疫治疗的潜在增强剂。 癌细胞中cGAS-STING信号的激活需要由内在或治疗诱导的DNA损伤产生的胞质DNA。然而，利用这种途径来改善免疫疗法的临床努力取得了有限的成功，突出了对 ...

A bacterium best known for causing gum disease may also influence how breast cancer begins and spreads. A team at the Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy r ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

A new fluorescent sensor is giving scientists an unprecedented view of how cells respond to DNA damage, capturing the repair process as it unfolds in real time. The tool, developed at Utrecht ...

Researchers at LUMC have made a breakthrough in understanding PALB2 mutations, an important cause of hereditary breast cancer ...

Chronically high levels of insulin and inflammation are key features of obesity and metabolic syndrome, which mediate cancer ...